藥典二氧化碳中碳氫化合物色譜測定，CO，CO2，CH4，芝麻香白酒，3-甲硫基丙醇，液化石油氣，頂空進樣器，粗苯，植物油

藥典二氧化碳中碳氫化合物色譜測定
藥典二氧化碳中碳氫化合物色譜測定 詳細信息：

二氧化碳EryanghuatanCarbon DioxideCO₂ 44.01
本品含CO₂不得少于99.5%(ml/ml)。
【性狀】 本品為無色氣體；無臭；水溶液顯弱酸性反應(yīng)。
本品1容在常壓20℃時，能溶于水約1容中。
【鑒別】 (1)取本品，通入氫氧化鋇試液中，即生成白色沉淀；沉淀能在醋酸中溶解并發(fā)生泡沸。
(2)本品能使火焰熄滅。
(3)本品的紅外光吸收圖譜應(yīng)與對照的圖譜(圖1)一致(通則0402)。
【檢查】 酸度 取水100ml，加甲基橙指示液0.2ml，混勻，分取各50ml，置甲、乙兩支比色管中，于乙管中，加鹽酸滴定液(0.01ml/L)1.0ml，搖勻；于甲管中，通入本品1000ml(速度為每小時4000ml)后，顯出的紅色不得較乙管深。
水分 取本品，通入露點分析儀測定，含水分不得過百萬分之六十七。
—氯化碳 取本品，用一氧化碳檢測管測定，含一氧化碳不得過百萬分之五
二氧化硫 取本品，用二氧化硫檢測管測定，含二氧化硫不得過百萬分之二。
磷化氫 取本品，用磷化氫檢測管測定，含磷化氫不得過千萬分之三。
硫化氫 取本品，用硫化氫檢測管測定，含硫化氫不得過百萬分之一。
氨 取本品，用氨檢測管測定，含氨不得過百萬分之二十五。
碳氫化合物 取本品作為供試品氣體，取甲烷含量為0.0020%的氣體(以氮氣為稀釋劑)作為對照氣體，照氣相色譜法(通則0521)試驗，用玻璃球為填料的色譜柱(4mm×0.8m，80目)；柱溫為110℃；進樣口溫度為110℃；檢測器為火焰離子化檢測器，溫度為120℃。量取供試品氣體與對照氣體，注入色譜儀，在凈化溫度為360℃時測得的峰面積為相應(yīng)空白值；量取供試品氣體與對照氣體，注入色譜儀，測定峰面積，減去相應(yīng)空白值后的峰面積為校正峰面積。按外標法以校正峰面積計算，含碳氫化合物(以甲烷計)不得過0.0020%。
【含量測定】 照氧項下的方法，除改用附圖所示的吸收器，并以氫氧化鉀溶液(1→2)125ml代替銅絲與氨-氯化銨溶液作為吸收液，并以酸化水(對甲基橙指示液顯酸性)取代飽和氯化鈉溶液注入平衡瓶J中外，依法操作，剩余的氣體體積恒定為止。讀取量氣管內(nèi)的液面刻度，算出供試品的含量，即得。

藥典二氧化碳中碳氫化合物的測定，敘述粗略，許多制藥企業(yè)很難操作，滕州市浩瀚色譜儀器技術(shù)服務(wù)有限公司，，，研發(fā)出藥典CO2中碳氫化合物測定的詳細的分析方案，歡迎咨詢洽談。

具體配置如下：

1.GC-7990氣相色譜儀

2.氫火焰檢測器FID

3.氣體進樣裝置

4.標準氣體：CH4/N2

5.填充柱：1m*1/8（安捷倫，島津。熱電及進口儀器用），0.8m*4mm，0.8*3mm（國產(chǎn)儀器用）

6.氫氣發(fā)生器HHH-300

7.空氣發(fā)生器：HHA-3L

8.氮氣鋼瓶及減壓閥

9.電腦，打印機

10.核心部件：凈化裝置（浩瀚色譜研制，）

藥典二氧化碳中碳氫化合物色譜測定 測試譜圖：



Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide
Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide Details:

Carbon dioxide Eryanghuatan Carbon DioxideCO2 44.01
This product contains not less than 99.5% CO2 (ml/ml).
【Properties】 This product is a colorless gas; odorless; aqueous solution is weakly acidic.
This product 1 can be dissolved in water at about 1 °C at normal pressure.
[Identification] (1) Take this product and pass it into the barium hydroxide test solution to form a white precipitate; the precipitate can be dissolved in acetic acid and bubbled.
(2) This product can extinguish the flame.
(3) The infrared absorption spectrum of this product should be consistent with the control map (Figure 1) (General Rule 0402).
[Check] Take 100ml of acidity, add 0.2ml of methyl orange indicator solution, mix well, take 50ml each, separate two colorimetric tubes of armor and B, add hydrochloric acid titration solution (0.01ml/L) in the tube. 1.0ml, shake well; in the tube, after entering 1000ml of this product (speed is 4000ml per hour), the red color should not be deeper than the tube.
Moisture Take this product and measure it with a dew point analyzer. The moisture content should not exceed 67 parts per million.
- Chlorinated carbon Take this product and measure it with carbon monoxide detector tube. The carbon monoxide should not exceed 5 parts per million.
Sulfur Dioxide Take this product and measure it with sulfur dioxide detection tube. The sulfur dioxide should not exceed 2 parts per million.
Phosphine is taken from this product and measured with a phosphine detector tube. The phosphine containing hydrogen should not exceed 3 parts per million.
Hydrogen sulfide Take this product and measure it with hydrogen sulfide detection tube. The hydrogen sulfide content should not exceed one part per million.
Ammonia Take this product and measure it with ammonia test tube. The ammonia content should not exceed 25 parts per million.
Hydrocarbon is taken as the test gas, and a gas with a methane content of 0.0020% (with nitrogen as a diluent) is used as a control gas, and gas chromatography (General Rule 0521) is used to test the column with glass spheres as a filler ( 4mm × 0.8m, 80 mesh); column temperature is 110 ° C; inlet temperature is 110 ° C; detector is flame ionization detector, temperature is 120 ° C. The test gas and the control gas are measured and injected into the chromatograph. The peak area measured at the purification temperature of 360 ° C is the corresponding blank value; the gas for the test sample and the control gas are taken, injected into the chromatograph, and the peak area is measured and reduced. The peak area after the corresponding blank value is the corrected peak area. According to the external standard method, the hydrocarbon content (in terms of methane) should not exceed 0.0020%.
[Content determination] In the method of oxygen, except that the absorber shown in the figure is used, and 125ml of potassium hydroxide solution (1→2) is used instead of copper wire and ammonia-ammonium chloride solution as the absorption liquid, and The acidified water (acidic to the methyl orange indicator liquid) is replaced by a saturated sodium chloride solution into the balance bottle J, and operated according to the law until the remaining gas volume is constant. Read the liquid level scale in the trachea and calculate the content of the test sample.


The determination of hydrocarbons in the Pharmacopoeia carbon dioxide is crude and many pharmaceutical companies are difficult to operate. Tengzhou Haohao Chromatography Instrument Technology Service Co., Ltd. keeps pace with the times and develops the determination of hydrocarbons in the Pharmacopoeia CO2 under the guidance of the scientific development concept. Detailed analysis plan, welcome to consult and negotiate.
The specific configuration is as follows:
1.GC-7990 Gas Chromatograph
2. Hydrogen flame detector FID
3. Gas sampling device
4. Standard gas: CH4/N2
5. Packed column: 1m*1/8 (Agilent, Shimadzu. Used for thermoelectric and imported instruments), 0.8m*4mm, 0.8*3mm (for domestic instruments)
6. Hydrogen generator HHH-300
7. Air generator: HHA-3L
8. Nitrogen cylinder and pressure reducing valve
9. Computer, printer
10. Core components: purification device (the development of vast chromatography, domestic original)


Chromatographic Determination of Hydrocarbons in Pharmacopoeia Carbon Dioxide Test Spectra: